STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGOS_AAL096WSulfurtransferase. (303 aa)    
Predicted Functional Partners:
NFS1
Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5- carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5- methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
 0.985
UBA4
Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...]
   
 0.973
AGOS_ABL077W
ABL077Wp.
    
 0.965
AGOS_AEL341W
AEL341Wp.
 
 
 0.955
AGOS_AFR211C
Aspartate aminotransferase.
  
 
 0.954
AGOS_ABL038W
Aspartate aminotransferase.
  
 
 0.954
AGOS_ACL059C
ACL059Cp.
  
 
 0.951
AGOS_AEL259W
AEL259Wp.
    
 0.927
AGOS_AGR237C
AGR237Cp.
    
 0.919
AGOS_AER164C
AER164Cp.
  
 
 0.884
Your Current Organism:
Eremothecium gossypii
NCBI taxonomy Id: 284811
Other names: Ashbya gossypii ATCC 10895, E. gossypii ATCC 10895, Eremothecium gossypii ATCC 10895
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.