STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rho3GTP-binding protein rho3; Involved in controlling cell shape and septation. Regulates cell separation by modulating the function of the exocyst complex. Involved in post-Golgi vesicle transport. (205 aa)    
Predicted Functional Partners:
exo70
Exocyst complex component exo70; Required for exocytosis; Belongs to the EXO70 family.
    
 
 0.987
for3
Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family.
    
 
 0.959
sec8
Exocyst complex component sec8; Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins.
    
 
 0.954
rga4
Probable Rho-type GTPase-activating protein 4; GTPase-activating protein for Rho-type proteins.
   
 0.939
rga3
Probable Rho-type GTPase-activating protein 3; GTPase-activating protein for Rho-type proteins.
   
 0.928
rdi1
Rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
   
 
 0.897
gef3
Rho guanine nucleotide exchange factor gef3; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.
    
 
 0.860
sec15
Exocyst complex component sec15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC15 family.
   
 
 0.856
exo84
Exocyst complex component exo84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
    
 
 0.816
sec10
Exocyst complex component sec10; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC10 family.
    
 
 0.791
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.