STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mgm101Mitochondrial genome maintenance protein mgm101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family. (270 aa)    
Predicted Functional Partners:
rim1
Single-stranded DNA-binding protein rim1, mitochondrial; This protein binds preferentially and cooperatively to ss- DNA. Involved in mitochondrial DNA replication (By similarity).
   
 
 0.860
por1
Probable mitochondrial outer membrane protein porin; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.
      
 0.757
mdm10
Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...]
      
 0.756
pfh1
ATP-dependent DNA helicase pfh1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase. Belongs to the helicase family. PIF1 subfamily.
   
 
 0.698
rsm18
37S ribosomal protein rsm18, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family.
   
  
 0.660
mdm12
Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...]
      
 0.648
msh1
MutS protein homolog 1; Involved in mitochondrial DNA repair; Belongs to the DNA mismatch repair MutS family.
    
 
 0.637
mrpl31
54S ribosomal protein L31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL60 family.
      
 0.628
fol1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the central section; belongs to the HPPK family.
   
  
 0.617
rib3
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
   
  
 0.575
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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