STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hip4Histone promoter control protein 2; Component of the HIR complex, which functions as a histone chaperone that cooperates with cia1/asf1 to promote replication- independent chromatin assembly. (338 aa)    
Predicted Functional Partners:
hip1
Protein hir1; Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase; Belongs to the WD repeat HIR1 family.
   
 0.999
slm9
Histone transcription regulator slm9; Probably required for replication-independent chromatin assembly (By similarity). Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. May play an indirect role in the regulation of cdc2 and/or wee1 at the G2/M stage of mitosis. Belongs to the WD repeat HIR1 family.
   
 0.998
hip3
Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Required for transcriptional silencing in the outer repeat (otr) region of centromeric repeats and the Tf2 long terminal repeat retrotransposons; Belongs to the HIR3 family.
   
 0.993
cia1
Histone chaperone cia1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
   
 
 0.948
SPAC926.02
UPF0656 protein C926.02.
   
  
 0.751
pcf2
Uncharacterized WD repeat-containing protein C26H5.03.
   
 
 0.622
pcf3
Uncharacterized WD repeat-containing protein C25H1.06.
    
 
 0.605
osr1
Uncharacterized oxidoreductase C663.06c.
    
 
 0.591
adh8
Zinc-type alcohol dehydrogenase-like protein C1773.06c.
   
 0.573
etp1
Electron transfer protein 1, mitochondrial.
   
 0.573
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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