STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccc2Copper-transporting ATPase ccc2; Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone atx1 and incorporates it into trans-Golgi vesicles (By similarity). (904 aa)    
Predicted Functional Partners:
atx1
Metal homeostasis factor atx1; Shuttles copper to the transport ATPase ccc2. Protects against oxygen toxicity (By similarity); Belongs to the ATX1 family.
    
 
 0.998
cox17
Cytochrome c oxidase copper chaperone; Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity). Belongs to the COX17 family.
      
 0.944
cuf1
Metal-binding regulatory protein cuf1; Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6.
    
 
 0.918
fio1
Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
  
 
 0.911
ctr4
Copper transport protein ctr4; Required for high affinity copper (probably reduced Cu I) transport into the cell.
    
 
 0.910
sco1
Protein sco1; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2); Belongs to the SCO1/2 family.
     
 0.894
cox1102
Cytochrome c oxidase assembly protein cox11-2; Rsm22-2 is involved in mitochondrion-encoded protein synthesis; In the C-terminal section; belongs to the COX11/CtaG family.
      
 0.882
rrn6
Uncharacterized protein C3B8.11.
    
 
 0.863
ccs1
Superoxide dismutase 1 copper chaperone; Copper chaperone for superoxide dismutase 1 (sod1). Binds copper ions and delivers them specifically to sod1. Also has a role in cell protection against copper ion toxicity during conditions of copper excess. The C-terminal region is thought to act specifically in this sequestration role; Belongs to the CCS1 family.
   
 
 0.841
cox1101
Cytochrome c oxidase assembly protein cox11-1; Rsm22-1 is involved in mitochondrion-encoded protein synthesis; In the C-terminal section; belongs to the COX11/CtaG family.
      
 0.835
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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