STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fnx2Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily. (577 aa)    
Predicted Functional Partners:
avt5
Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.
   
 
 0.877
agp3
Uncharacterized amino-acid permease C965.11c.
   
 
 0.737
atg22
Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.
   
  
 0.716
put4
Probable proline-specific permease put4; Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as non- specific GABA permease. Can also transport alanine and glycine (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
   
 
 0.668
isp5
Sexual differentiation process putative amino-acid permease isp5; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
   
 
 0.630
fxn1
Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity); Belongs to the frataxin family.
      
 0.575
aat1
Amino acid transporter 1; Probable amino acid transporter that may play a role in function in microtubule organization since it causes microtubule defects when overexpressed; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
   
 
 0.473
isp6
Sexual differentiation process putative subtilase-type proteinase isp6.
   
 
 0.469
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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