node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ani1 | chz1 | O74191 | Q10239 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Histone H2A.Z-specific chaperone chz1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. | 0.781 |
ani1 | doa10 | O74191 | O60103 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...] | 0.743 |
ani1 | erb1 | O74191 | O74399 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.763 |
ani1 | fkh1 | O74191 | O42993 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Has an important role in sexual development and serves as the target for rapamycin action; Belongs to the FKBP-type PPIase family. FKBP1 subfamily. | 0.736 |
ani1 | nhp2 | O74191 | Q9P7H0 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | H/ACA ribonucleoprotein complex subunit nhp2; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (By similarity). The H/ACA snoRNP complex mediates pseudourid [...] | 0.730 |
ani1 | noc201 | O74191 | Q9P7G0 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Uncharacterized NOC2 family protein C1142.04. | 0.722 |
ani1 | nop2 | O74191 | O94268 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | 25S rRNA (cytosine-C(5))-methyltransferase nop2; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (By similarity). | 0.747 |
ani1 | nop58 | O74191 | Q9P7S7 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. | 0.797 |
ani1 | rpf2 | O74191 | Q9UUG1 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | Ribosome production factor 2 homolog. | 0.803 |
ani1 | spb1 | O74191 | O42832 | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | AdoMet-dependent rRNA methyltransferase spb1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | 0.725 |
chz1 | ani1 | Q10239 | O74191 | Histone H2A.Z-specific chaperone chz1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | 0.781 |
doa10 | ani1 | O60103 | O74191 | ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...] | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | 0.743 |
doa10 | fkh1 | O60103 | O42993 | ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...] | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Has an important role in sexual development and serves as the target for rapamycin action; Belongs to the FKBP-type PPIase family. FKBP1 subfamily. | 0.467 |
erb1 | ani1 | O74399 | O74191 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity). | 0.763 |
erb1 | fkh1 | O74399 | O42993 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Has an important role in sexual development and serves as the target for rapamycin action; Belongs to the FKBP-type PPIase family. FKBP1 subfamily. | 0.452 |
erb1 | nhp2 | O74399 | Q9P7H0 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | H/ACA ribonucleoprotein complex subunit nhp2; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (By similarity). The H/ACA snoRNP complex mediates pseudourid [...] | 0.802 |
erb1 | noc201 | O74399 | Q9P7G0 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | Uncharacterized NOC2 family protein C1142.04. | 0.997 |
erb1 | nop2 | O74399 | O94268 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 25S rRNA (cytosine-C(5))-methyltransferase nop2; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (By similarity). | 0.997 |
erb1 | nop58 | O74399 | Q9P7S7 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. | 0.968 |
erb1 | rpf2 | O74399 | Q9UUG1 | Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | Ribosome production factor 2 homolog. | 0.995 |