STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rlp1DNA repair protein rlp1; Required for normal levels of meiotic recombination. Acts in the recombinational pathway of double-strand break (DSB) repair together with rhp51, rhp55 and rad22. Required for the full extent of DNA recombination and cell survival under condition of a replication fork collapse; Belongs to the RecA family. RAD51 subfamily. (363 aa)    
Predicted Functional Partners:
sws1
Zinc finger SWIM domain-containing protein sws1; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
    
 
 0.904
rdl1
DNA repair protein rdl1; Involved in homologous recombination where it functions at an early stage of recombination in a pre-recombinogenic complex with rlp1 and sws1. Also has a role at a later stage of recombination in association with the rhp55-rhp57 complex.
    
 
 0.904
sfr1
Swi5-dependent recombination DNA repair protein 1; Involved in DNA recombination repair and meiotic chromosome segregation; Belongs to the SFR1/MEI5 family.
   
 
 0.804
dbl7
Uncharacterized protein C651.12c.
   
 
 0.730
SPAC22G7.03
Uncharacterized protein C22G7.03.
   
 
 0.726
shu1
Uncharacterized GPI-anchored protein C1F8.02c.
      
 0.630
rad55
DNA repair protein rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways.
   
  
 0.629
rad57
DNA repair protein rhp57; Involved in recombination DNA repair and in the repair of gamma-ray-induced damage.
    
 
 0.624
dmc1
Meiotic recombination protein dmc1; Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments. Belongs to the RecA family. DMC1 subfamily.
    
 
 0.563
fml1
ATP-dependent DNA helicase fml1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinantion during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. FANCM-MHF also promotes non- crossover recombination in meiotic cells.
   
  
 0.558
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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