STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
met11Methylenetetrahydrofolate reductase 2; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 15 to 20 percent of the total methylenetetrahydrofolate reductase activity of the cells. (641 aa)    
Predicted Functional Partners:
met9
Methylenetetrahydrofolate reductase 1; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 80 to 85 percent of the total methylenetetrahydrofolate reductase activity of the cells.
  
 
0.997
shm2
Serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine; Belongs to the SHMT family.
  
 
 0.987
mtd1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]; Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.
    
 0.986
thf1
C-1-tetrahydrofolate synthase, cytoplasmic; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.
  
 
 0.974
shm1
Probable serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine; Belongs to the SHMT family.
  
 
 0.966
hal3
Probable thymidylate synthase; Required for both nuclear and mitochondrial DNA synthesis. In the N-terminal section; belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily.
  
 
 0.964
gcv1
Probable aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
  
 
 0.960
ade9
C-1-tetrahydrofolate synthase, mitochondrial; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.
  
 
 0.945
met26
Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.938
SPAC57A7.07c
Uncharacterized protein C57A7.07c.
  
 
 0.869
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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