STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppk24Serine/threonine-protein kinase ppk24, mitochondrial; Has a role late in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (461 aa)    
Predicted Functional Partners:
mug30
Probable E3 ubiquitin-protein ligase mug30; Probable E3 ubiquitin-protein ligase. Has a role in meiosis.
   
  
 0.757
hry1
Uncharacterized hemerythrin-like protein C869.06c.
   
  
 0.757
SPAP14E8.05c
TMEM14 protein homolog P14E8.05c.
      
 0.752
cox5
Cytochrome c oxidase polypeptide 5, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembr [...]
      
 0.723
SPBPB2B2.06c
Uncharacterized protein PB2B2.06c.
   
  
 0.626
bio2
Biotin synthase; Belongs to the radical SAM superfamily. Biotin synthase family.
      
 0.550
cdc45
Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4. Belongs to the CDC45 family.
   
 
 0.548
rad3
Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily.
    
 
 0.526
mde3
Sporulation protein kinase mde3; Protein kinase which is essential for spore formation.
  
   0.521
cds1
Serine/threonine-protein kinase cds1; Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
  
 
0.515
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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