STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mfm2M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor. (44 aa)    
Predicted Functional Partners:
mfm3
M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor.
   
  
 0.874
mfm1
M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor.
   
  
 0.873
SPAC513.04
Uncharacterized protein C513.04.
   
  
 0.638
map2
P-factor-like 1; In h- cells under nutritional starvation, P-factor induces alteration of cell morphology toward mating, arrest of the cell cycle at the G1 phase prior to the initiation of DNA synthesis and indirect transcriptional activation of the sxa2 gene which down-regulates the signaling pathway.
   
  
 0.580
map3
Pheromone M-factor receptor; Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient.
      
 0.571
mam2
Pheromone P-factor receptor; Receptor for the peptide pheromone P-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; P-factor signaling alone may be sufficient; Belongs to the G-protein coupled receptor 4 family.
   
  
 0.554
ste11
Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'.
   
  
 0.543
ste4
Sexual differentiation protein ste4; Essential for mating and meiosis.
   
  
 0.500
sxa2
Carboxypeptidase sxa2; Involved in degradation or processing of the mating pheromones. Its loss causes a persistent response to the pheromones. It may be required for stabilization of enzymes that are essential for zygote formation. May degrade the mating pheromone P-factor.
      
 0.493
gpa1
Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily.
   
  
 0.463
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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