STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ypt5GTP-binding protein ypt5; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (211 aa)    
Predicted Functional Partners:
pik3
Phosphatidylinositol 3-kinase vps34; Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation; Belongs to the PI3/PI4-kinase family.
    
 0.987
muk1
Vacuolar protein sorting-associated protein 9b.
   
 
 0.960
vps8
Vacuolar protein sorting-associated protein 8; Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process (By similarity); Belongs to the VPS8 family.
    
 
 0.943
pep7
Vacuolar segregation protein pep7; Required for vacuole segregation and vacuole protein sorting. Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins. Probably functions in several interorganelle traffic pathways (By similarity).
   
 
 0.935
vps901
Vacuolar protein sorting-associated protein 9a; Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors.
    
 
 0.923
gdi1
Probable secretory pathway GDP dissociation inhibitor 1; Belongs to the Rab GDI family.
   
 
 0.919
vam6
Vacuolar morphogenesis protein 6; Required for vacuolar assembly. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (By similarity).
   
 
 0.903
pep3
Vacuolar membrane protein pep3; Required for vacuolar biogenesis; Belongs to the VPS18 family.
   
 
 0.885
vps16
Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology (By similarity).
    
 
 0.879
vps33
Vacuolar protein sorting-associated protein 33; Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole.
    
 
 0.831
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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