STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
php3Transcriptional activator hap3; Belongs to a complex that binds to the sequence CCAAT located upstream of genes involved in mitochondrial electron transport. (116 aa)    
Predicted Functional Partners:
php2
Transcriptional activator hap2; Global regulator of respiratory functions in yeast cells. It belongs to a complex that binds to the sequence CCAAT located upstream of genes involved in mitochondrial electron transport.
   
 0.999
php5
Transcriptional activator hap5; Component of the CCAAT-bound heteromer, php5 is essential for DNA-binding activity. It is essential for transcription activation of cyc1. It is the linchpin that binds to the subunit association domains (SAD) of php2 and php3 to bring these proteins together.
  
 0.999
php4
CCAAT-binding factor complex subunit php4; Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Downregulates pcl1, sdh4, and isa1 underlow-iron conditions.
   
 
 0.974
fep1
Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3.
   
 
 0.911
dpb3
DNA polymerase epsilon subunit C; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair (By similarity). The dpb3-dpb4 dimer associates with histone deacetylases, chromatin remodelers, and hi [...]
   
 
 0.883
rst2
Zinc finger protein rst2; Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter.
    
 
 0.771
fra3
Uncharacterized bolA-like protein C4B3.11c.
      
 0.630
grx4
Monothiol glutaredoxin-4; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (By similarity).
      
 0.629
rrn3
RNA polymerase I-specific transcription initiation factor rrn3; Required for efficient transcription initiation by RNA polymerase I; Belongs to the RRN3 family.
 
 
    0.610
tbp1
TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
    
 
 0.562
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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