STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rec12Meiotic recombination protein rec12; Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II. (345 aa)    
Predicted Functional Partners:
rec14
Meiotic recombination protein rec14; Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination.
    
 
 0.989
rec6
Meiotic recombination protein rec6; Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May be involved primarily in the early steps of meiotic recombination (Probable); Belongs to the TOP6B-like family.
   
 
 0.978
rec8
Meiotic recombination protein rec8; Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Belongs to the rad21 family.
   
 
 0.968
dmc1
Meiotic recombination protein dmc1; Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments. Belongs to the RecA family. DMC1 subfamily.
   
 
 0.946
rec7
Meiotic recombination protein rec7; May be involved primarily in the early steps of meiotic recombination.
   
  
 0.945
rec10
Meiotic recombination protein rec10; Involved primarily in the early steps of meiotic recombination localized to chromosome III.
    
 
 0.936
mre11
DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family.
   
 
 0.929
rec15
Meiotic recombination protein rec15; Required during the early stages of meiosis for meiotic recombination. Involved in chromosome segregation where it is required for separation of sister chromatids in all three chromosomes.
   
  
 0.918
mus81
Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the XPF family.
    
 
 0.915
rec11
Meiotic recombination protein rec11.
   
 
 0.910
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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