STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rhp16ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family. (861 aa)    
Predicted Functional Partners:
rhp7
DNA repair protein rhp7; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp16, after UV irradiation. Belongs to the RAD7 family.
   
 0.996
rad16
DNA repair protein rad16; Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion. Belongs to the XPF family.
     
 0.940
his5
Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.
  
 
 0.940
his7
Histidine biosynthesis bifunctional protein his7.
  
 
 0.939
his3
Histidinol-phosphate aminotransferase.
  
 
 0.939
his1
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
  
 
 0.939
his6
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.
  
 
 0.938
his4
Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family.
  
 
 0.922
ckn1
DNA excision repair protein ckn1; Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair.
     
 0.891
swi10
Mating-type switching protein swi10; Involved in termination of copy-synthesis during mating-type switching. Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD16 forms an endonuclease that specifically degrades single-stranded DNA; Belongs to the ERCC1/RAD10/SWI10 family.
     
 0.876
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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