STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
erg2C-8 sterol isomerase erg2; Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins. (219 aa)    
Predicted Functional Partners:
erg6
Sterol 24-C-methyltransferase erg6; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol (Probable). Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.
   
 0.999
erg31
Delta(7)-sterol 5(6)-desaturase erg31; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins. Belongs to the sterol desaturase family.
   
 0.998
erg24
Delta(14)-sterol reductase; Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta- 8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Belongs to the ERG4/ERG24 family.
   
 
 0.997
erg25
Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.
   
 0.997
erg11
Lanosterol 14-alpha demethylase erg11; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol.
   
 
 0.996
erg32
Delta(7)-sterol 5(6)-desaturase erg32; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins. Belongs to the sterol desaturase family.
   
 0.994
erg1
Probable squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
   
 
 0.994
erg26
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family.
   
 
 0.986
erg28
Ergosterol biosynthetic protein 28; May have a role in anchoring erg26 and erg27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction (By similarity); Belongs to the ERG28 family.
   
 
 0.982
erg4
Delta(24(24(1)))-sterol reductase.
   
 
 0.972
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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