STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tht1Nuclear fusion protein tht1; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family. (577 aa)    
Predicted Functional Partners:
mcp4
Meiotic coiled-coil protein 4; Has a role in meiosis.
   
  
 0.752
his2
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
      
 0.732
dhc1
Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase.
   
  
 0.475
sec63
Translocation protein sec63; Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec63 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to allow more efficient polypeptide interaction. May also be involved in S [...]
      
 0.475
mcp6
Meiotic coiled-coil protein 6; Has a role in meiotic nuclear oscillation and recombination. Required to remodel astral microtubules into the 'horsetail' astral array maintaining the 'horsetail' nuclear movement. Promotes homologous paring of chromosomes during this movement.
      
 0.426
mcp7
Meiotic coiled-coil protein 7; Required for meiotic recombination.
      
 0.422
meu14
Meiotic expression up-regulated protein 14; Has a role in nuclear division during meiosis II where it stabilizes the proper segregation of the spindle pole bodies. Also has a role in the formation and extension of the forespore membrane.
   
  
 0.401
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.