STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alp1Tubulin-folding cofactor D; Has a function in the folding of beta-tubulin. Microtubule- associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis. (1105 aa)    
Predicted Functional Partners:
alp21
Cell polarity protein alp21; Required for microtubule and spindle assembly. Involved in the proper folding of alpha-tubulin.
   
 0.999
tbc1
Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family.
    
 0.992
alp41
ADP-ribosylation factor-like protein alp41; Has a role in the cofactor-dependent pathway of microtubule biogenesis. Required for growth polarity control. Belongs to the small GTPase superfamily. Arf family.
   
 
 0.986
alp11
Cell polarity protein alp11; Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin.
    
 
 0.971
nda3
Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
    
 
 0.917
alp31
Tubulin-specific chaperone A; Required for the maintenance of microtubule structures and cell polarity. Beta-tubulin-folding protein; may have a regulatory role in the tubulin-folding pathway.
    
 
 0.883
nce103
Carbonic anhydrase; Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate- dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase (By similarity); Belongs to the beta-class carbonic anhydrase family.
  
  
 0.848
mad2
Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family.
    
   0.655
adh4
Alcohol dehydrogenase 4; Involved in ethanol oxidation in mitochondria. Belongs to the iron-containing alcohol dehydrogenase family.
  
  
 0.652
sir1
Sulfite reductase [NADPH] subunit beta; Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.
     
 0.629
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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