STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
imp2Septation protein imp2; Required for normal septation. Involved in the disassembly of the medial ring during septation. (670 aa)    
Predicted Functional Partners:
fic1
Ingression protein fic1; Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins.
    
 
 0.994
pxl1
LIM domain-containing protein C4F6.12.
   
 
 0.953
cyk3
Cytokinesis protein 3; Involved in cytokinesis; Belongs to the CYK3 family.
   
 
 0.941
cdc15
Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.
  
0.930
rgf3
Rho1 guanine nucleotide exchange factor 3; Stimulates the exchange of Rho1 GDP-bound form into GTP-bound form. Regulates, via interaction and activation of Rho1, beta-1,3- glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly.
    
 
 0.903
rga7
Probable Rho-GTPase-activating protein 7.
   
 
 0.895
myp2
Myosin type-2 heavy chain 2; Stabilizes the F-actin cables forming the F-actin ring that surrounds the nucleus during interphase. May work in conjunction with myo2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 
 0.866
aps2
AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
    
 0.791
myo2
Myosin type-2 heavy chain 1; Required for cell division. It is a component of the cdc12 'spot', a structure thought to mark the site of septation. May work in conjunction with myo3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 
 0.790
rlc1
Myosin regulatory light chain 1.
    
 
 0.787
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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