STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
opy1Uncharacterized PH domain-containing protein PB16A4.02c. (339 aa)    
Predicted Functional Partners:
ypp1
Putative cargo-transport protein ypp1; Involved in endocytosis; Belongs to the YPP1 family.
   
  
 0.761
efr3
Protein efr3; Belongs to the EFR3 family.
   
  
 0.755
plc1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
   
 
  0.702
its3
Phosphatidylinositol 4-phosphate 5-kinase its3; Involved, together with the calcineurin ppb1, in cytokinesis.
   
 
 0.637
cog5
Conserved oligomeric Golgi complex subunit 5; Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra- Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
   
 
 0.546
sog2
Leucine-rich repeat-containing protein sog2.
   
 
 0.546
adf1
Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...]
   
 
 0.540
pob1
Protein pob1; Has a role in cell elongation and separation.
    
 
 0.491
stg1
Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring.
   
  
 0.479
snd1
Staphylococcal nuclease domain-containing protein 1.
    
 
 0.475
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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