STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
abc3ATP-binding cassette transporter abc3; Iron-regulated vacuolar ABC-type transporter which may be responsible for mobilizing stored iron from the vacuole to the cytosol in response to iron deficiency. (1465 aa)    
Predicted Functional Partners:
ATP-binding cassette transporter abc2; Involved in vacuolar sequestration of glutathione S- conjugates. Together with abc4, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway.
Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).
Uncharacterized protein C24H6.11c.
Plasma membrane iron permease; Permease for high affinity iron uptake. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
Leptomycin B resistance protein pmd1; May be a transmembrane transporter of the mating factor, namely P-factor or M-factor. Confers resistance to leptomycin B and to several other antifungal drugs; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Mating factor M secretion protein mam1; Required in S.pombe M (minus) cells for production of M- factor pheromone. Involved in the transport of the farnesyl-derivation of the M-factor pheromone; Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family.
GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome.
ATP-binding cassette transporter abc4; Involved in detoxification of xenobiotics, and vacuolar sequestration of glutathione S-conjugates. Together with abc2, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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