STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sft2Protein transport protein sft2; Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Can be replaced by got1 (By similarity); Belongs to the SFT2 family. (201 aa)    
Predicted Functional Partners:
got1
Protein transport protein got1; Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by sft2 (By similarity); Belongs to the GOT1 family.
   
 
 0.759
aps3
AP-3 complex subunit sigma; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
   
  
 0.738
vps1302
Vacuolar protein sorting-associated protein 13b; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family.
      
 0.723
sed5
Integral membrane protein sed5; Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE) (By similarity); Belongs to the syntaxin family.
    
 
 0.720
gos1
Protein transport protein gos1; Nonessential SNARE involved in retrograde transport within the Golgi complex.
   
 
 0.664
erp2
Uncharacterized membrane protein C17A5.08.
   
  
 0.634
vps71
SWR1 complex subunit vps71; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
   
  
 0.632
apl4
AP-1 complex subunit gamma-1; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin (By similarity).
   
  
 0.574
apl6
AP-3 complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).
      
 0.570
ryh1
GTP-binding protein ryh1; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in protein transport to the plasma membrane. Involved in the secretory pathway where it has a role in acid phosphatase secretion. Required also in normal glycosylation trafficking pathways; Belongs to the small GTPase superfamily. Rab family.
    
 
 0.560
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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