STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
set13Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (rpl42) at 'Lys-55'; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (468 aa)    
Predicted Functional Partners:
pdp1
PWWP domain-containing protein 1; Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.
   
  
 0.870
rmt2
Protein arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.
   
  
 0.827
rmt1
Protein arginine N-methyltransferase 1; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Asymmetrically dimethylates the polyadenylate-binding protein pab2, modulating pab2 oligomerization.
   
  
 0.777
rmt3
Ribosomal protein arginine N-methyltransferase rmt3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
   
  
 0.774
nob1
20S-pre-rRNA D-site endonuclease nob1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm (By similarity).
   
    0.700
rpl42
60S ribosomal protein L42; Belongs to the eukaryotic ribosomal protein eL42 family.
   
 
 0.694
set9
Histone-lysine N-methyltransferase set9; Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form H4K20me3. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage.
   
  
 0.652
pdp2
PWWP domain-containing protein2.
   
  
 0.612
set11
Ribosomal lysine N-methyltransferase set11; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates 60S ribosomal protein L12 (rpl1201 and rpl1202) at 'Lys-4' and may dimethylate L12 also at 'Lys-40' and 'Lys-41'. Overexpression causes a severe growth defect. Has a role in meiosis; Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.
   
 
 0.568
rpc82
DNA-directed RNA polymerase III subunit rpc3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
   
  
 0.553
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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