STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aco2Homocitrate dehydratase, mitochondrial; Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (918 aa)    
Predicted Functional Partners:
cit1
Probable citrate synthase, mitochondrial; Belongs to the citrate synthase family.
  
 0.938
idp1
Probable isocitrate dehydrogenase [NADP], mitochondrial.
  
 0.928
SPBC365.16
Uncharacterized membrane protein C365.16.
   
 
 0.892
idh2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle and is involved in glutamate biosynthesis. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
  
 0.889
yml6
54S ribosomal protein yml6, mitochondrial; Belongs to the universal ribosomal protein uL4 family.
   
 
 0.886
icl1
Mitochondrial 2-methylisocitrate lyase; Catalyzes the formation of pyruvate and succinate from 2- methylisocitrate during the metabolism of endogenous propionyl-CoA. Does not act on isocitrate (By similarity); Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
  
 0.812
kgd1
2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
  
 
 0.803
idh1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.
  
 0.777
SPAC750.08c
NAD-dependent malic enzyme (Predicted), partial.
   
  
 0.770
SPBP4H10.18c
Uncharacterized protein P4H10.18c.
      
 0.760
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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