STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cgr1rRNA-processing protein cgr1; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Belongs to the CGR1 family. (111 aa)    
Predicted Functional Partners:
rpf2
Ribosome production factor 2 homolog.
   
 
 0.990
rrs1
Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly.
   
   0.983
nsa2
Ribosome biogenesis protein nsa2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
   
 
 0.968
rsa4
Ribosome assembly protein 4; Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP- dependent dissociation of a group of nonribosomal factors from the pre- 60S particle.
   
 
 0.956
nog2
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
   
 
 0.947
nog1
Probable nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
   
 
 0.931
arx1
Probable metalloprotease arx1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
   
 
 0.928
rlp24
Ribosome biogenesis protein rlp24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of nog1 to pre-60S particles. Activates and recruits ATPase afg2 to cytoplasmic pre-60S ribosomal particles.
   
 
 0.928
ppp1
Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
   
   0.903
rrp16
Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.
   
 
 0.885
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.