STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cnb1Calcineurin subunit B; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity). (174 aa)    
Predicted Functional Partners:
ppb1
Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape; Belongs to the PPP phosphatase family. PP-2B subfamily.
   
 0.999
fkh1
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Has an important role in sexual development and serves as the target for rapamycin action; Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
   
 
 0.991
cch1
Calcium-channel protein cch1; Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca(2+) are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity).
    
 
 0.939
prz1
Transcriptional regulator prz1; Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates pmc1.
    
 
 0.860
cam2
Myosin 1 light chain cam2; Plays a role in meiosis and sporulation.
   
 
 0.845
rcn1
Uncharacterized protein C13G6.15c; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.
    
 
 0.838
cdc31
Cell division control protein 31; Required for the proper coordination between exit from mitosis and the initiation of septation. Has a role in bipolar spindle formation during spindle pole body (SPB) duplication. Required for the localization of sad1 to the SPB.
   
  
 0.716
vcx1
Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole (By similarity); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
 
 0.703
myo1
Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating.
    
 
 0.668
pph3
Putative serine/threonine-protein phosphatase C26H8.05c; Belongs to the PPP phosphatase family. PP-1 subfamily.
    
 0.662
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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