STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sfk1Protein sfk1; May control the production of phosphatidylinositol 4- phosphate (PI4P); Belongs to the SFK1 family. (328 aa)    
Predicted Functional Partners:
stt4
Phosphatidylinositol 4-kinase stt4; Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate.
   
 
 0.879
erg25
Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.
   
 
 0.771
erg7
Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
  
 0.762
erg1
Probable squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
   
 0.761
erg4
Delta(24(24(1)))-sterol reductase.
   
 0.754
erg6
Sterol 24-C-methyltransferase erg6; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol (Probable). Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.
   
 
 0.729
ypp1
Putative cargo-transport protein ypp1; Involved in endocytosis; Belongs to the YPP1 family.
      
 0.717
trp1
Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
  
  
 0.681
erg27
3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols.
    
 
 0.675
elo1
Putative elongation of fatty acids protein 2; May be involved in the synthesis of very long chain fatty acids.
   
  
 0.671
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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