STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vps3Vacuolar protein sorting-associated protein 3; Required for sorting and processing of soluble vacuolar proteins; Belongs to the VPS3 family. (910 aa)    
Predicted Functional Partners:
vps16
Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology (By similarity).
   
 0.999
vps8
Vacuolar protein sorting-associated protein 8; Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process (By similarity); Belongs to the VPS8 family.
   
 0.998
pep3
Vacuolar membrane protein pep3; Required for vacuolar biogenesis; Belongs to the VPS18 family.
   
 0.998
vps33
Vacuolar protein sorting-associated protein 33; Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole.
   
 0.998
vps11
E3 ubiquitin-protein ligase pep5; Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between [...]
   
 0.990
vps41
Vacuolar protein sorting-associated protein 41; Required for vacuolar assembly and vacuolar traffic.
   
 
 0.990
vam6
Vacuolar morphogenesis protein 6; Required for vacuolar assembly. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (By similarity).
   
 
 0.989
SPAC16A10.03c
Pep5-like zinc finger protein C16A10.03c.
   
 
 0.887
aut12
Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family.
   
 
 0.862
pep12
Syntaxin pep12; Has a role in vesicle-mediated transport but not with protein transport from Golgi to vesicle; Belongs to the syntaxin family.
    
 
 0.834
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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