STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADRX_ENCCUAdrenodoxin homolog; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (128 aa)    
Predicted Functional Partners:
Q8SQU7_ENCCU
NADPH ADRENODOXIN OXIDOREDUCTASE.
   
 0.998
NFS1
Cysteine desulfurase, mitosomal; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters in mitosomes; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 0.992
ISU1
Iron sulfur cluster assembly protein 1; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe- 2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desul [...]
  
 0.967
YFH1
Frataxin, mitosomal; Promotes the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways.
   
 
 0.905
Q8SSG5_ENCCU
HSB-LIKE CHAPERONE.
  
  
 0.882
Q8SSF2_ENCCU
THIOREDOXIN REDUCTASE.
   
 
 0.821
NAR1
Cytosolic Fe-S cluster assembly factor NAR1; Component of the cytosolic Fe/S protein assembly machinery. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
    
 
 0.782
Q8SS06_ENCCU
NADPH CYTOCHROME P450 REDUCTASE.
   
 
 0.737
Q8STL9_ENCCU
Putative oxidoreductase.
   
 
 0.737
Q8SRZ9_ENCCU
ACETYLCOENZYME A SYNTHETASE.
    
 0.669
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
Server load: low (16%) [HD]