STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRS6B_ENCCU26S proteasome regulatory subunit 6B homolog; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family. (387 aa)    
Predicted Functional Partners:
RPT6
26S proteasome regulatory subunit 8 homolog; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family.
 
0.999
RPN11
26S proteasome regulatory subunit RPN11; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the peptidase M67A family.
  
 0.999
RPT5
26S proteasome regulatory subunit 6A; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family.
  
0.999
Q8SR59_ENCCU
PROTEASOME ALPHA SUBUNIT C6.
  
 0.999
Q8SR64_ENCCU
26S PROTEASOME REGULATORY SUBUNIT S5A.
   
 0.999
RPT2
26S proteasome regulatory subunit 4 homolog; Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity); Belongs to the AAA ATPase family.
 
0.999
Q8SRM0_ENCCU
26S PROTEASOME REGULATORY SUBUNIT 10; Belongs to the AAA ATPase family.
  
0.999
Q8SS61_ENCCU
26S PROTEASOME REGULATORY SUBUNIT 12.
  
 0.999
Q8SS82_ENCCU
26S PROTEASOME REGULATORY SUBUNIT 7; Belongs to the AAA ATPase family.
 
0.999
Q8SUH5_ENCCU
PCI domain-containing protein.
   
 0.999
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.