STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NDC80Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (543 aa)    
Predicted Functional Partners:
NUF2
Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
  
 0.999
Q8SU30_ENCCU
Uncharacterized protein.
   
 0.999
Q8STZ9_ENCCU
Uncharacterized protein.
    
 
 0.946
MPS1
Probable serine/threonine-protein kinase MPS1 homolog; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
   
 
 0.932
IPL1
Probable spindle assembly checkpoint kinase homolog; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
   
 
 0.905
Q8SSJ9_ENCCU
CHROMOSOME SEGREGATION PROTEIN.
   
 
 0.885
Q8SRL6_ENCCU
REQUIRED FOR NUCLEAR DIVISION (SPINDLE POLE BODY DUPLICATION) CUT1_SCHPO.
   
 
 0.857
Q8SR35_ENCCU
KINESIN-RELATED PROTEIN; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.851
Q8SRD0_ENCCU
POLY(A)+ RNA EXPORT PROTEIN.
   
 0.831
Q8SVK6_ENCCU
Uncharacterized protein.
   
  
 0.793
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
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