STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NFS1Cysteine desulfurase, mitosomal; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters in mitosomes; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (432 aa)    
Predicted Functional Partners:
ISU1
Iron sulfur cluster assembly protein 1; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe- 2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desul [...]
  
 0.999
Q8SW12_ENCCU
Rhodanese domain-containing protein.
   
 0.999
YFH1
Frataxin, mitosomal; Promotes the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways.
   
 0.999
ADRX_ENCCU
Adrenodoxin homolog; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
 
 0.992
Q8SSG5_ENCCU
HSB-LIKE CHAPERONE.
  
 
 0.880
Q8SR88_ENCCU
Proteasome subunit beta.
 
      0.732
GLO2_ENCCU
Probable hydroxyacylglutathione hydrolase ECU02_0580; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  
 
 0.724
HSP70
Mitochondrial-type heat shock protein 70; May act as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 0.719
AMPL_ENCCU
Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity).
  
  
 0.670
Q8SQU7_ENCCU
NADPH ADRENODOXIN OXIDOREDUCTASE.
   
  
 0.651
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
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