STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC7-1Probable cell division control protein 7 homolog 1; Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis (By similarity). (351 aa)    
Predicted Functional Partners:
Q8SRS4_ENCCU
DNA helicase; Belongs to the MCM family.
   
 0.988
Q8SRF0_ENCCU
DNA helicase; Belongs to the MCM family.
   
 0.987
Q8SRX5_ENCCU
DNA REPLICATION LICENSING FACTOR OF THE MCM FAMILY (MCM6); Belongs to the MCM family.
   
 0.985
Q8SS42_ENCCU
DNA helicase; Belongs to the MCM family.
   
 0.985
Q8SSE5_ENCCU
DNA helicase; Belongs to the MCM family.
   
 0.985
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
    
 0.983
CDC7-2
Probable cell division control protein 7 homolog 2; Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis (By similarity).
  
  
 
0.900
Q8SVH2_ENCCU
DBF4-type domain-containing protein.
   
 0.872
Q8SS92_ENCCU
ORIGIN RECOGNITION COMPLEX SUBUNIT 1.
   
 0.759
MEC1
Probable serine/threonine-protein kinase MEC1 homolog; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and [...]
    
 0.756
Your Current Organism:
Encephalitozoon cuniculi
NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1
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