TK protein (Encephalitozoon cuniculi) - STRING interaction network

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Predicted Interactions

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Score

TK

Thymidine kinase. (232 aa)

Predicted Functional Partners:

Q8SS22_ENCCU

0.995

TS-1

0.988

TS-3

0.988

DUT1

0.967

DHFR-1

0.946

PYRG_ENCCU

0.878

SHMT-1

0.870

Q8SQZ1_ENCCU

0.815

SEC53

0.793

Q8SUB9_ENCCU

0.788

Your Current Organism:

Encephalitozoon cuniculi

NCBI taxonomy Id: 284813
Other names: E. cuniculi GB-M1, Encephalitozoon cuniculi GB-M1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHFR-1	DUT1	O62583	Q8SRS0	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.634
DHFR-1	PYRG_ENCCU	O62583	Q8SQI7	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.470
DHFR-1	Q8SQZ1_ENCCU	O62583	Q8SQZ1	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Triosephosphate isomerase.	0.631
DHFR-1	Q8SS22_ENCCU	O62583	Q8SS22	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	THYMIDYLATE KINASE.	0.963
DHFR-1	SEC53	O62583	Q8SVM5	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the eukaryotic PMM family.	0.440
DHFR-1	SHMT-1	O62583	O62585	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family.	0.995
DHFR-1	TK	O62583	O96720	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Thymidine kinase.	0.946
DHFR-1	TS-1	O62583	O62584	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Thymidylate synthase 1/2; Belongs to the thymidylate synthase family.	0.997
DHFR-1	TS-3	O62583	Q8SRG2	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	Thymidylate synthase 3; Belongs to the thymidylate synthase family.	0.997
DUT1	DHFR-1	Q8SRS0	O62583	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	0.634
DUT1	Q8SS22_ENCCU	Q8SRS0	Q8SS22	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	THYMIDYLATE KINASE.	0.958
DUT1	SHMT-1	Q8SRS0	O62585	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family.	0.401
DUT1	TK	Q8SRS0	O96720	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidine kinase.	0.967
DUT1	TS-1	Q8SRS0	O62584	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate synthase 1/2; Belongs to the thymidylate synthase family.	0.972
DUT1	TS-3	Q8SRS0	Q8SRG2	Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate synthase 3; Belongs to the thymidylate synthase family.	0.972
PYRG_ENCCU	DHFR-1	Q8SQI7	O62583	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).	0.470
PYRG_ENCCU	Q8SQZ1_ENCCU	Q8SQI7	Q8SQZ1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	Triosephosphate isomerase.	0.707
PYRG_ENCCU	Q8SS22_ENCCU	Q8SQI7	Q8SS22	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	THYMIDYLATE KINASE.	0.794
PYRG_ENCCU	SHMT-1	Q8SQI7	O62585	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family.	0.641
PYRG_ENCCU	TK	Q8SQI7	O96720	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	Thymidine kinase.	0.878