STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1014 aa)    
Predicted Functional Partners:
SFF08246.1
L-glutamine synthetase.
     
 0.942
SFF08135.1
L-glutamine synthetase.
 
   
 0.903
SFE87069.1
[protein-PII] uridylyltransferase; Belongs to the GlnD family.
 
   
 0.760
SFE87031.1
Nitrogen regulatory protein P-II family.
 
 
 
 0.723
SFF06414.1
Ribonuclease D.
  
     0.695
panB
Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.686
SFF06921.1
Protein of unknown function.
  
     0.672
SFF02677.1
MerR HTH family regulatory protein.
  
     0.643
crgA
Uncharacterised protein family (UPF0233); Involved in cell division; Belongs to the CrgA family.
      
 0.623
SFF00185.1
Glutamate synthase (NADH) large subunit.
     
 0.618
Your Current Organism:
Sanguibacter marinus
NCBI taxonomy Id: 285351
Other names: CGMCC 1.3457, DSM 19083, JCM 12547, S. marinus, Sanguibacter marinus Huang et al. 2005 emend. Pikuta et al. 2017, Sanguibacter sp. 1-19, strain 1-19
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.