STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFF34497.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (471 aa)    
Predicted Functional Partners:
SFF34443.1
Pyruvate dehydrogenase E1 component alpha subunit.
 0.999
SFF34464.1
Pyruvate dehydrogenase E1 component beta subunit.
 0.999
SFF07978.1
Dihydrolipoamide dehydrogenase.
 0.997
SFF05784.1
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component.
 0.989
SFF29839.1
2-oxoglutarate dehydrogenase E1 component.
 
0.986
SFF08634.1
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.983
SFE82977.1
Dihydrolipoamide dehydrogenase.
 0.971
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.970
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.962
SFE82062.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.961
Your Current Organism:
Sanguibacter marinus
NCBI taxonomy Id: 285351
Other names: CGMCC 1.3457, DSM 19083, JCM 12547, S. marinus, Sanguibacter marinus Huang et al. 2005 emend. Pikuta et al. 2017, Sanguibacter sp. 1-19, strain 1-19
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.