node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCE64189.1 | SCE78265.1 | GA0070561_0459 | GA0070561_1607 | Cobalamin-independent synthase, Catalytic domain. | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | 0.527 |
SCE64189.1 | SCF21117.1 | GA0070561_0459 | GA0070561_4300 | Cobalamin-independent synthase, Catalytic domain. | Hypothetical protein; Belongs to the GcvT family. | 0.645 |
SCE64189.1 | SCF39187.1 | GA0070561_0459 | GA0070561_6124 | Cobalamin-independent synthase, Catalytic domain. | Aminomethyltransferase. | 0.734 |
SCE64189.1 | gcvH | GA0070561_0459 | GA0070561_2061 | Cobalamin-independent synthase, Catalytic domain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.804 |
SCE64189.1 | gcvP | GA0070561_0459 | GA0070561_2075 | Cobalamin-independent synthase, Catalytic domain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.930 |
SCE64189.1 | glyA | GA0070561_0459 | GA0070561_1954 | Cobalamin-independent synthase, Catalytic domain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.418 |
SCE78265.1 | SCE64189.1 | GA0070561_1607 | GA0070561_0459 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Cobalamin-independent synthase, Catalytic domain. | 0.527 |
SCE78265.1 | SCF21117.1 | GA0070561_1607 | GA0070561_4300 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Hypothetical protein; Belongs to the GcvT family. | 0.744 |
SCE78265.1 | SCF21136.1 | GA0070561_1607 | GA0070561_4302 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | 4-amino-4-deoxychorismate lyase. | 0.726 |
SCE78265.1 | SCF39187.1 | GA0070561_1607 | GA0070561_6124 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Aminomethyltransferase. | 0.822 |
SCE78265.1 | gcvH | GA0070561_1607 | GA0070561_2061 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.895 |
SCE78265.1 | gcvP | GA0070561_1607 | GA0070561_2075 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.984 |
SCE78265.1 | glyA | GA0070561_1607 | GA0070561_1954 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.772 |
SCF21105.1 | SCF21117.1 | GA0070561_4299 | GA0070561_4300 | Uncharacterized conserved protein, DUF849 family. | Hypothetical protein; Belongs to the GcvT family. | 0.861 |
SCF21105.1 | SCF21126.1 | GA0070561_4299 | GA0070561_4301 | Uncharacterized conserved protein, DUF849 family. | Nickel uptake regulator, Fur family; Manually curated; Belongs to the Fur family. | 0.861 |
SCF21105.1 | SCF21136.1 | GA0070561_4299 | GA0070561_4302 | Uncharacterized conserved protein, DUF849 family. | 4-amino-4-deoxychorismate lyase. | 0.510 |
SCF21117.1 | SCE64189.1 | GA0070561_4300 | GA0070561_0459 | Hypothetical protein; Belongs to the GcvT family. | Cobalamin-independent synthase, Catalytic domain. | 0.645 |
SCF21117.1 | SCE78265.1 | GA0070561_4300 | GA0070561_1607 | Hypothetical protein; Belongs to the GcvT family. | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). | 0.744 |
SCF21117.1 | SCF21105.1 | GA0070561_4300 | GA0070561_4299 | Hypothetical protein; Belongs to the GcvT family. | Uncharacterized conserved protein, DUF849 family. | 0.861 |
SCF21117.1 | SCF21126.1 | GA0070561_4300 | GA0070561_4301 | Hypothetical protein; Belongs to the GcvT family. | Nickel uptake regulator, Fur family; Manually curated; Belongs to the Fur family. | 0.876 |