PISL3812_02074 protein (Talaromyces islandicus)

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

PISL3812_02074

Uncharacterized protein. (352 aa)

Predicted Functional Partners:

PISL3812_09709

0.611

PISL3812_00016

0.609

PISL3812_08936

0.609

PISL3812_09191

0.607

nahG

0.555

BNA5

0.529

BNA5-2

0.529

PISL3812_04815

0.528

COQ3

0.528

PISL3812_02958

0.499

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA5	BNA5-2	A0A0U1LJG1	A0A0U1LTP4	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.891
BNA5	PISL3812_00016	A0A0U1LJG1	A0A0U1LIP9	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Tryptophan synthase.	0.637
BNA5	PISL3812_02074	A0A0U1LJG1	A0A0U1LNV3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.529
BNA5	PISL3812_08936	A0A0U1LJG1	A0A0U1M966	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Tryptophan synthase.	0.637
BNA5-2	BNA5	A0A0U1LTP4	A0A0U1LJG1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.891
BNA5-2	PISL3812_00016	A0A0U1LTP4	A0A0U1LIP9	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Tryptophan synthase.	0.637
BNA5-2	PISL3812_02074	A0A0U1LTP4	A0A0U1LNV3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.529
BNA5-2	PISL3812_08936	A0A0U1LTP4	A0A0U1M966	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Tryptophan synthase.	0.637
COQ3	PISL3812_02074	A0A0U1M9P5	A0A0U1LNV3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.528
PISL3812_00016	BNA5	A0A0U1LIP9	A0A0U1LJG1	Tryptophan synthase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.637
PISL3812_00016	BNA5-2	A0A0U1LIP9	A0A0U1LTP4	Tryptophan synthase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.637
PISL3812_00016	PISL3812_02074	A0A0U1LIP9	A0A0U1LNV3	Tryptophan synthase.	Uncharacterized protein.	0.609
PISL3812_00016	PISL3812_08936	A0A0U1LIP9	A0A0U1M966	Tryptophan synthase.	Tryptophan synthase.	0.999
PISL3812_00016	PISL3812_09191	A0A0U1LIP9	A0A0U1M996	Tryptophan synthase.	Uncharacterized protein.	0.478
PISL3812_00016	PISL3812_09709	A0A0U1LIP9	A0A0U1MCH4	Tryptophan synthase.	Putative CDP-alcohol phosphatidyltransferase class-I family protein C22A12,08c.	0.819
PISL3812_00016	nahG	A0A0U1LIP9	A0A0U1LS88	Tryptophan synthase.	FAD_binding_3 domain-containing protein.	0.592
PISL3812_02074	BNA5	A0A0U1LNV3	A0A0U1LJG1	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.529
PISL3812_02074	BNA5-2	A0A0U1LNV3	A0A0U1LTP4	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.529
PISL3812_02074	COQ3	A0A0U1LNV3	A0A0U1M9P5	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.528
PISL3812_02074	PISL3812_00016	A0A0U1LNV3	A0A0U1LIP9	Uncharacterized protein.	Tryptophan synthase.	0.609

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.913

expected number of edges:

11

PPI enrichment p-value:

0.000548

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015995

Chlorophyll biosynthetic process

5 of 19

1.9

2.4

5.97e-06

GO:0036068

Light-independent chlorophyll biosynthetic process

2 of 7

1.94

0.89

0.0205

GO:0019685

Photosynthesis, dark reaction

2 of 7

1.94

0.89

0.0205

GO:0019438

Aromatic compound biosynthetic process

6 of 226

0.91

0.67

0.0043

GO:0018130

Heterocycle biosynthetic process

6 of 243

0.88

0.63

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

3 of 22

1.62

0.73

0.0357

GO:0016730

Oxidoreductase activity, acting on iron-sulfur proteins as donors

2 of 5

2.09

0.73

0.0450

GO:0016636

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

2 of 4

2.18

0.73

0.0450

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 38

1.38

0.64

0.0450

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30083465

(2018) Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates.

4 of 22

1.74

1.11

0.0055

PMID:34295515

(2021) Characterizing the supercomplex association of photosynthetic complexes in cyanobacteria.

3 of 12

1.88

0.76

0.0356

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4585

Chlorophyll metabolic process

5 of 16

1.98

2.79

9.24e-07

CL:4583

Porphyrin-containing compound biosynthetic process

6 of 29

1.8

2.74

2.59e-07

CL:4587

Chlorophyll metabolic process

4 of 10

2.09

2.48

8.80e-06

CL:4589

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor, and Enoyl-(Acyl carrier protein) reductase

2 of 5

2.09

0.93

0.0183

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

can00860

Porphyrin and chlorophyll metabolism

5 of 55

1.44

1.56

6.64e-05

can01110

Biosynthesis of secondary metabolites

7 of 272

0.9

0.79

0.00032

can01100

Metabolic pathways

7 of 590

0.56

0.36

0.0311

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0149

Chlorophyll biosynthesis

3 of 13

1.85

1.25

0.0031

KW-0004

4Fe-4S

3 of 37

1.39

0.73

0.0259

KW-0602

Photosynthesis

3 of 58

1.2

0.59

0.0454

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00148

Nitrogenase component 1 type Oxidoreductase

2 of 2

2.48

0.85

0.0287

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