PISL3812_03115 protein (Talaromyces islandicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PISL3812_03115

Protein hob1. (409 aa)

Predicted Functional Partners:

PISL3812_05605

0.960

PISL3812_03179

0.959

PISL3812_06930

0.955

CLTC

0.903

PISL3812_05865

0.818

PISL3812_03426

0.812

PISL3812_02115

0.793

PISL3812_09208

0.767

PISL3812_06901

0.709

PISL3812_04503

0.707

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLTC	PISL3812_03115	A0A0U1LY20	A0A0U1LSJ5	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Protein hob1.	0.903
CLTC	PISL3812_03179	A0A0U1LY20	A0A0U1LTS6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Proline-rich protein LAS17.	0.866
CLTC	PISL3812_03426	A0A0U1LY20	A0A0U1LV20	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Septation protein imp2.	0.937
CLTC	PISL3812_04503	A0A0U1LY20	A0A0U1LW88	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Vacuolar dynamin-like GTPase VpsA, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.864
CLTC	PISL3812_05605	A0A0U1LY20	A0A0U1LZ19	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Protein hob3.	0.943
CLTC	PISL3812_05865	A0A0U1LY20	A0A0U1M1B7	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Actin, gamma.	0.639
CLTC	PISL3812_06901	A0A0U1LY20	A0A0U1M399	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Polyphosphatidylinositol phosphatase INP52.	0.778
CLTC	PISL3812_06930	A0A0U1LY20	A0A0U1M4E2	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Protein app1.	0.504
CLTC	PISL3812_09208	A0A0U1LY20	A0A0U1M9Y6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Actin cytoskeleton-regulatory complex protein sla1.	0.558
PISL3812_02115	PISL3812_03115	A0A0U1LNZ0	A0A0U1LSJ5	WH2 domain-containing protein.	Protein hob1.	0.793
PISL3812_02115	PISL3812_03179	A0A0U1LNZ0	A0A0U1LTS6	WH2 domain-containing protein.	Proline-rich protein LAS17.	0.993
PISL3812_02115	PISL3812_03426	A0A0U1LNZ0	A0A0U1LV20	WH2 domain-containing protein.	Septation protein imp2.	0.603
PISL3812_02115	PISL3812_05605	A0A0U1LNZ0	A0A0U1LZ19	WH2 domain-containing protein.	Protein hob3.	0.658
PISL3812_02115	PISL3812_05865	A0A0U1LNZ0	A0A0U1M1B7	WH2 domain-containing protein.	Actin, gamma.	0.793
PISL3812_02115	PISL3812_06901	A0A0U1LNZ0	A0A0U1M399	WH2 domain-containing protein.	Polyphosphatidylinositol phosphatase INP52.	0.445
PISL3812_02115	PISL3812_06930	A0A0U1LNZ0	A0A0U1M4E2	WH2 domain-containing protein.	Protein app1.	0.533
PISL3812_02115	PISL3812_09208	A0A0U1LNZ0	A0A0U1M9Y6	WH2 domain-containing protein.	Actin cytoskeleton-regulatory complex protein sla1.	0.816
PISL3812_03115	CLTC	A0A0U1LSJ5	A0A0U1LY20	Protein hob1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.903
PISL3812_03115	PISL3812_02115	A0A0U1LSJ5	A0A0U1LNZ0	Protein hob1.	WH2 domain-containing protein.	0.793
PISL3812_03115	PISL3812_03179	A0A0U1LSJ5	A0A0U1LTS6	Protein hob1.	Proline-rich protein LAS17.	0.959

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.826

expected number of edges:

11

PPI enrichment p-value:

0.00675

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019333

Denitrification pathway

3 of 3

2.6

2.03

0.00030

GO:0042128

Nitrate assimilation

3 of 5

2.38

1.92

0.00041

GO:0006825

Copper ion transport

2 of 2

2.6

1.24

0.0075

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050421

Nitrite reductase (NO-forming) activity

3 of 3

2.6

2.19

0.00016

GO:0005507

Copper ion binding

3 of 9

2.12

1.87

0.00036

GO:0046914

Transition metal ion binding

4 of 116

1.14

0.75

0.0124

GO:0046872

Metal ion binding

7 of 448

0.79

0.62

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3523

Mixed, incl. Heavy-metal-associated domain, and Copper ion binding

5 of 17

2.07

3.11

5.70e-07

CL:3525

Mixed, incl. Copper ion binding, and P-type ATPase, subfamily IB

4 of 10

2.2

2.81

5.18e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042597

Periplasmic space

5 of 150

1.12

0.85

0.0045

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07732

Multicopper oxidase

3 of 3

2.6

2.25

0.00012

PF00394

Multicopper oxidase

3 of 3

2.6

2.25

0.00012

PF00403

Heavy-metal-associated domain

2 of 4

2.3

1.05

0.0148

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045087

Multicopper oxidase

3 of 3

2.6

2.02

0.00032

IPR033138

Multicopper oxidases, conserved site

3 of 3

2.6

2.02

0.00032

IPR011707

Multicopper oxidase, N-terminal

3 of 3

2.6

2.02

0.00032

IPR011706

Multicopper oxidase, C-terminal

3 of 3

2.6

2.02

0.00032

IPR002355

Multicopper oxidase, copper-binding site

3 of 3

2.6

2.02

0.00032

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About