PISL3812_07306 protein (Talaromyces islandicus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

PISL3812_07306

Multidrug resistance protein 1A. (1207 aa)

Predicted Functional Partners:

PISL3812_03100

0.671

ACC1

0.637

PISL3812_00244

0.578

PISL3812_06456

0.547

PISL3812_07497

0.509

PISL3812_00538

0.507

PISL3812_03738

0.504

PISL3812_05303

0.504

PISL3812_09378

0.500

PISL3812_01307

0.493

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACC1	PISL3812_03738	A0A0U1M568	A0A0U1LTJ3	Biotin carboxylase.	Ubiquinol-cytochrome c reductase core subunit 2.	0.625
ACC1	PISL3812_06456	A0A0U1M568	A0A0U1M322	Biotin carboxylase.	Mitochondrial processing peptidase; Belongs to the peptidase M16 family.	0.693
ACC1	PISL3812_07306	A0A0U1M568	A0A0U1M3U3	Biotin carboxylase.	Multidrug resistance protein 1A.	0.637
PISL3812_00244	PISL3812_07306	A0A0U1LIQ8	A0A0U1M3U3	Endocytosis protein end4.	Multidrug resistance protein 1A.	0.578
PISL3812_00538	PISL3812_07306	A0A0U1LJL6	A0A0U1M3U3	Ubiquitin carboxyl-terminal hydrolase.	Multidrug resistance protein 1A.	0.507
PISL3812_01307	PISL3812_05303	A0A0U1LP83	A0A0U1LY56	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	26S protease regulatory subunit 7 homolog; Belongs to the AAA ATPase family.	0.999
PISL3812_01307	PISL3812_07306	A0A0U1LP83	A0A0U1M3U3	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	Multidrug resistance protein 1A.	0.493
PISL3812_03100	PISL3812_07306	A0A0U1LRR7	A0A0U1M3U3	Pheromone P-factor receptor.	Multidrug resistance protein 1A.	0.671
PISL3812_03738	ACC1	A0A0U1LTJ3	A0A0U1M568	Ubiquinol-cytochrome c reductase core subunit 2.	Biotin carboxylase.	0.625
PISL3812_03738	PISL3812_06456	A0A0U1LTJ3	A0A0U1M322	Ubiquinol-cytochrome c reductase core subunit 2.	Mitochondrial processing peptidase; Belongs to the peptidase M16 family.	0.999
PISL3812_03738	PISL3812_07306	A0A0U1LTJ3	A0A0U1M3U3	Ubiquinol-cytochrome c reductase core subunit 2.	Multidrug resistance protein 1A.	0.504
PISL3812_05303	PISL3812_01307	A0A0U1LY56	A0A0U1LP83	26S protease regulatory subunit 7 homolog; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
PISL3812_05303	PISL3812_07306	A0A0U1LY56	A0A0U1M3U3	26S protease regulatory subunit 7 homolog; Belongs to the AAA ATPase family.	Multidrug resistance protein 1A.	0.504
PISL3812_06456	ACC1	A0A0U1M322	A0A0U1M568	Mitochondrial processing peptidase; Belongs to the peptidase M16 family.	Biotin carboxylase.	0.693
PISL3812_06456	PISL3812_03738	A0A0U1M322	A0A0U1LTJ3	Mitochondrial processing peptidase; Belongs to the peptidase M16 family.	Ubiquinol-cytochrome c reductase core subunit 2.	0.999
PISL3812_06456	PISL3812_07306	A0A0U1M322	A0A0U1M3U3	Mitochondrial processing peptidase; Belongs to the peptidase M16 family.	Multidrug resistance protein 1A.	0.547
PISL3812_07306	ACC1	A0A0U1M3U3	A0A0U1M568	Multidrug resistance protein 1A.	Biotin carboxylase.	0.637
PISL3812_07306	PISL3812_00244	A0A0U1M3U3	A0A0U1LIQ8	Multidrug resistance protein 1A.	Endocytosis protein end4.	0.578
PISL3812_07306	PISL3812_00538	A0A0U1M3U3	A0A0U1LJL6	Multidrug resistance protein 1A.	Ubiquitin carboxyl-terminal hydrolase.	0.507
PISL3812_07306	PISL3812_01307	A0A0U1M3U3	A0A0U1LP83	Multidrug resistance protein 1A.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.493

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.438

expected number of edges:

10

PPI enrichment p-value:

3.58e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050660

Flavin adenine dinucleotide binding

8 of 57

1.69

3.25

2.57e-10

GO:0009055

Electron transfer activity

9 of 75

1.62

3.21

2.96e-11

GO:0016491

Oxidoreductase activity

11 of 420

0.96

1.15

8.03e-09

GO:0043167

Ion binding

10 of 1117

0.49

0.37

0.0070

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1289

0.47

0.39

0.00093

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1846

Electron transfer flavoprotein domain, and Acyl-CoA dehydrogenase, conserved site

10 of 25

2.14

6.77

9.77e-18

CL:1848

Electron transfer flavoprotein domain, and Acyl-CoA dehydrogenase, conserved site

9 of 18

2.24

6.73

2.37e-16

CL:1851

Electron transfer flavoprotein domain, and Fatty acid beta-oxidation, unsaturated, even number

8 of 13

2.33

6.45

8.71e-15

CL:1853

Electron transfer flavoprotein, alpha/beta-subunit, N-terminal

3 of 5

2.32

2.11

9.64e-05

CL:1867

Electron transfer flavoprotein domain

2 of 5

2.14

0.99

0.0138

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005759

Mitochondrial matrix

7 of 11

2.34

5.75

6.80e-13

GOCC:0005739

Mitochondrion

9 of 49

1.8

4.23

3.71e-13

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 202

1.23

1.91

1.21e-10

GOCC:0005737

Cytoplasm

10 of 1016

0.53

0.44

0.00048

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00766

Electron transfer flavoprotein FAD-binding domain

7 of 7

2.54

6.25

2.99e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001308

Electron transfer flavoprotein alpha subunit/FixB

7 of 7

2.54

6.07

7.61e-13

IPR014730

Electron transfer flavoprotein, alpha/beta-subunit, N-terminal

7 of 12

2.31

5.31

5.56e-12

IPR014731

Electron transfer flavoprotein, alpha subunit, C-terminal

6 of 6

2.54

5.23

5.21e-11

IPR029035

DHS-like NAD/FAD-binding domain superfamily

6 of 11

2.28

4.46

5.20e-10

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

7 of 61

1.6

2.56

4.09e-08

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00893

Electron transfer flavoprotein domain

8 of 14

2.3

6.43

5.74e-15

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