PISL3812_07833 protein (Talaromyces islandicus)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PISL3812_07833

PNP_UDP_1 domain-containing protein. (288 aa)

Predicted Functional Partners:

PISL3812_09802

0.913

PISL3812_08855

0.877

PISL3812_05541

0.815

PISL3812_03527

0.710

PISL3812_00871

0.661

PISL3812_00269

0.649

PISL3812_03849

0.643

PISL3812_04548

0.642

PISL3812_02671

0.641

PISL3812_06484

0.641

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PISL3812_00269	PISL3812_07833	A0A0U1LJG8	A0A0U1M597	Uncharacterized protein.	PNP_UDP_1 domain-containing protein.	0.649
PISL3812_00871	PISL3812_03527	A0A0U1LKG6	A0A0U1LV43	Kinesin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	TPR_REGION domain-containing protein.	0.661
PISL3812_00871	PISL3812_05541	A0A0U1LKG6	A0A0U1M0I5	Kinesin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.661
PISL3812_00871	PISL3812_07833	A0A0U1LKG6	A0A0U1M597	Kinesin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	PNP_UDP_1 domain-containing protein.	0.661
PISL3812_02671	PISL3812_03527	A0A0U1LSU2	A0A0U1LV43	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.641
PISL3812_02671	PISL3812_03849	A0A0U1LSU2	A0A0U1LTU6	Uncharacterized protein.	Cell division control protein 73.	0.999
PISL3812_02671	PISL3812_05541	A0A0U1LSU2	A0A0U1M0I5	Uncharacterized protein.	Uncharacterized protein.	0.641
PISL3812_02671	PISL3812_07833	A0A0U1LSU2	A0A0U1M597	Uncharacterized protein.	PNP_UDP_1 domain-containing protein.	0.641
PISL3812_02671	PISL3812_09802	A0A0U1LSU2	A0A0U1MB14	Uncharacterized protein.	Uncharacterized protein.	0.736
PISL3812_03527	PISL3812_00871	A0A0U1LV43	A0A0U1LKG6	TPR_REGION domain-containing protein.	Kinesin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.661
PISL3812_03527	PISL3812_02671	A0A0U1LV43	A0A0U1LSU2	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.641
PISL3812_03527	PISL3812_03849	A0A0U1LV43	A0A0U1LTU6	TPR_REGION domain-containing protein.	Cell division control protein 73.	0.643
PISL3812_03527	PISL3812_04548	A0A0U1LV43	A0A0U1LY23	TPR_REGION domain-containing protein.	Anaphase-promoting complex subunit CDC16.	0.642
PISL3812_03527	PISL3812_06484	A0A0U1LV43	A0A0U1M1L0	TPR_REGION domain-containing protein.	Anaphase-promoting complex subunit 10.	0.641
PISL3812_03527	PISL3812_07833	A0A0U1LV43	A0A0U1M597	TPR_REGION domain-containing protein.	PNP_UDP_1 domain-containing protein.	0.710
PISL3812_03527	PISL3812_09802	A0A0U1LV43	A0A0U1MB14	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.861
PISL3812_03849	PISL3812_02671	A0A0U1LTU6	A0A0U1LSU2	Cell division control protein 73.	Uncharacterized protein.	0.999
PISL3812_03849	PISL3812_03527	A0A0U1LTU6	A0A0U1LV43	Cell division control protein 73.	TPR_REGION domain-containing protein.	0.643
PISL3812_03849	PISL3812_05541	A0A0U1LTU6	A0A0U1M0I5	Cell division control protein 73.	Uncharacterized protein.	0.643
PISL3812_03849	PISL3812_07833	A0A0U1LTU6	A0A0U1M597	Cell division control protein 73.	PNP_UDP_1 domain-containing protein.	0.643

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.23e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

8 of 17

2.07

4.9

2.49e-12

GO:2001295

malonyl-CoA biosynthetic process

2 of 4

2.1

0.96

0.0159

GO:0044281

Small molecule metabolic process

9 of 458

0.69

0.58

0.00035

GO:0071704

Organic substance metabolic process

11 of 1212

0.36

0.29

0.0098

GO:0044238

Primary metabolic process

10 of 999

0.4

0.29

0.0198

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 7

2.16

2.31

2.74e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 41

1.48

1.52

0.00014

GO:0000036

Acyl carrier activity

2 of 2

2.4

1.02

0.0133

GO:0003989

acetyl-CoA carboxylase activity

2 of 3

2.22

1.01

0.0133

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.0

0.93

0.0169

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

1.07

0.0096

GO:0005737

Cytoplasm

11 of 997

0.44

0.36

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1342

Fatty acid metabolism, and Alpha/beta hydrolase fold

7 of 13

2.13

4.56

6.41e-11

CL:1345

Fatty acid metabolism

4 of 8

2.1

2.57

5.86e-06

CL:1199

Mixed, incl. Pyruvate metabolism, and Citrate cycle (TCA cycle)

8 of 91

1.34

1.94

6.37e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pace01212

Fatty acid metabolism

6 of 10

2.18

4.29

5.66e-10

pace00061

Fatty acid biosynthesis

6 of 10

2.18

4.29

5.66e-10

pace00780

Biotin metabolism

4 of 11

1.96

2.46

5.80e-06

pace01100

Metabolic pathways

9 of 530

0.63

0.53

0.00035

pace01110

Biosynthesis of secondary metabolites

5 of 249

0.7

0.42

0.0351

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

0.84

0.0276

GOCC:0005737

Cytoplasm

10 of 756

0.52

0.39

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

5 of 9

2.14

3.49

4.57e-08

KW-0444

Lipid biosynthesis

6 of 21

1.85

3.07

4.33e-08

KW-0596

Phosphopantetheine

2 of 2

2.4

1.33

0.0035

KW-0012

Acyltransferase

3 of 24

1.5

1.05

0.0044

KW-0963

Cytoplasm

6 of 253

0.77

0.56

0.0057

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 2

2.4

0.77

0.0390

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