PISL3812_09162 protein (Talaromyces islandicus)

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Known Interactions

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Predicted Interactions

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Score

PISL3812_09162

Uncharacterized protein. (601 aa)

Predicted Functional Partners:

PISL3812_04287

0.854

PISL3812_04212

0.797

PISL3812_00437

0.737

PISL3812_00299

0.737

PISL3812_02160

0.737

PISL3812_01519

0.737

PISL3812_01951

0.737

PISL3812_03031

0.737

PISL3812_03962

0.737

PISL3812_07819

0.737

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PISL3812_00299	PISL3812_04212	A0A0U1LJK6	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.849
PISL3812_00299	PISL3812_04287	A0A0U1LJK6	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.736
PISL3812_00299	PISL3812_09162	A0A0U1LJK6	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_00437	PISL3812_04212	A0A0U1LJA5	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.921
PISL3812_00437	PISL3812_04287	A0A0U1LJA5	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.846
PISL3812_00437	PISL3812_09162	A0A0U1LJA5	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_01519	PISL3812_04212	A0A0U1LPS6	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.849
PISL3812_01519	PISL3812_04287	A0A0U1LPS6	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.736
PISL3812_01519	PISL3812_09162	A0A0U1LPS6	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_01951	PISL3812_04212	A0A0U1LQS1	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.849
PISL3812_01951	PISL3812_04287	A0A0U1LQS1	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.736
PISL3812_01951	PISL3812_09162	A0A0U1LQS1	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_02160	PISL3812_04212	A0A0U1LP57	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.921
PISL3812_02160	PISL3812_04287	A0A0U1LP57	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.846
PISL3812_02160	PISL3812_09162	A0A0U1LP57	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_03031	PISL3812_04212	A0A0U1LRN3	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.849
PISL3812_03031	PISL3812_04287	A0A0U1LRN3	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.736
PISL3812_03031	PISL3812_09162	A0A0U1LRN3	A0A0U1M919	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.737
PISL3812_03962	PISL3812_04212	A0A0U1LU67	A0A0U1LVF4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Squalene monooxygenase.	0.849
PISL3812_03962	PISL3812_04287	A0A0U1LU67	A0A0U1LXD6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.736

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.917

expected number of edges:

13

PPI enrichment p-value:

0.462

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8254

Mixed, incl. Phosphopantetheine, and Wax biosynthesis

4 of 22

2.69

3.79

3.64e-07

CL:8266

Wax biosynthesis, and Polyketide synthase, ketoreductase domain

3 of 6

3.13

3.52

1.65e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163765

ChREBP activates metabolic gene expression

3 of 18

2.65

2.53

5.88e-05

MAP-199220

Vitamin B5 (pantothenate) metabolism

3 of 22

2.56

2.51

5.88e-05

MAP-75105

Fatty acyl-CoA biosynthesis

3 of 40

2.3

2.16

0.00018

MAP-163685

Integration of energy metabolism

3 of 60

2.13

1.89

0.00044

MAP-8978868

Fatty acid metabolism

3 of 162

1.69

1.16

0.0063

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

4 of 12

2.95

5.03

3.85e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

4 of 12

2.95

4.6

2.10e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

4 of 12

2.95

4.34

6.02e-08

IPR009081

Phosphopantetheine binding ACP domain

4 of 12

2.95

4.34

6.02e-08

IPR013968

Polyketide synthase, ketoreductase domain

3 of 8

3.0

3.1

7.79e-06

IPR006162

Phosphopantetheine attachment site

2 of 6

2.95

1.51

0.0035

IPR036291

NAD(P)-binding domain superfamily

3 of 210

1.58

0.74

0.0434

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 7

2.88

1.59

0.0025

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