PISL3812_09555 protein (Talaromyces islandicus)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

PISL3812_09555

Broad-range acid phosphatase DET1. (603 aa)

Predicted Functional Partners:

PISL3812_00289

0.681

PISL3812_01592

0.676

PISL3812_00196

0.661

PISL3812_07320

0.650

PISL3812_02846

0.619

PISL3812_02052

0.613

PISL3812_05786

0.607

PISL3812_05158

0.597

PISL3812_06208

0.597

PISL3812_04116

0.587

Your Current Organism:

Talaromyces islandicus

NCBI taxonomy Id: 28573
Other names: ATCC 10127, CBS 338.48, IMI 040042, MUCL 31324, Penicillium islandicum, T. islandicus, Talaromyces islandicus (Sopp) Samson, Yilmaz, Frisvad & Seifert 2012

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PISL3812_00196	PISL3812_02052	A0A0U1LKI9	A0A0U1LR92	60S ribosomal protein L21-A.	54S ribosomal protein RML2, mitochondrial.	0.993
PISL3812_00196	PISL3812_02846	A0A0U1LKI9	A0A0U1LR09	60S ribosomal protein L21-A.	60S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family.	0.999
PISL3812_00196	PISL3812_04116	A0A0U1LKI9	A0A0U1LWR8	60S ribosomal protein L21-A.	60S ribosomal protein L2.	0.999
PISL3812_00196	PISL3812_07320	A0A0U1LKI9	A0A0U1M3Y4	60S ribosomal protein L21-A.	Ubiquitin-60S ribosomal protein L40.	0.999
PISL3812_00196	PISL3812_09555	A0A0U1LKI9	A0A0U1MA17	60S ribosomal protein L21-A.	Broad-range acid phosphatase DET1.	0.661
PISL3812_00289	PISL3812_02052	A0A0U1LJJ6	A0A0U1LR92	Cell surface glycoprotein 1; Belongs to the complex I LYR family.	54S ribosomal protein RML2, mitochondrial.	0.523
PISL3812_00289	PISL3812_09555	A0A0U1LJJ6	A0A0U1MA17	Cell surface glycoprotein 1; Belongs to the complex I LYR family.	Broad-range acid phosphatase DET1.	0.681
PISL3812_01592	PISL3812_05158	A0A0U1LMJ1	A0A0U1LZH7	Glycerophosphodiester phosphodiesterase GDE1.	26S proteasome regulatory subunit rpn11.	0.481
PISL3812_01592	PISL3812_06208	A0A0U1LMJ1	A0A0U1M172	Glycerophosphodiester phosphodiesterase GDE1.	NLPC_P60 domain-containing protein.	0.481
PISL3812_01592	PISL3812_07320	A0A0U1LMJ1	A0A0U1M3Y4	Glycerophosphodiester phosphodiesterase GDE1.	Ubiquitin-60S ribosomal protein L40.	0.591
PISL3812_01592	PISL3812_09555	A0A0U1LMJ1	A0A0U1MA17	Glycerophosphodiester phosphodiesterase GDE1.	Broad-range acid phosphatase DET1.	0.676
PISL3812_02052	PISL3812_00196	A0A0U1LR92	A0A0U1LKI9	54S ribosomal protein RML2, mitochondrial.	60S ribosomal protein L21-A.	0.993
PISL3812_02052	PISL3812_00289	A0A0U1LR92	A0A0U1LJJ6	54S ribosomal protein RML2, mitochondrial.	Cell surface glycoprotein 1; Belongs to the complex I LYR family.	0.523
PISL3812_02052	PISL3812_02846	A0A0U1LR92	A0A0U1LR09	54S ribosomal protein RML2, mitochondrial.	60S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family.	0.980
PISL3812_02052	PISL3812_05786	A0A0U1LR92	A0A0U1LZZ9	54S ribosomal protein RML2, mitochondrial.	Mitochondrial import receptor subunit tom-40.	0.461
PISL3812_02052	PISL3812_07320	A0A0U1LR92	A0A0U1M3Y4	54S ribosomal protein RML2, mitochondrial.	Ubiquitin-60S ribosomal protein L40.	0.992
PISL3812_02052	PISL3812_09555	A0A0U1LR92	A0A0U1MA17	54S ribosomal protein RML2, mitochondrial.	Broad-range acid phosphatase DET1.	0.613
PISL3812_02846	PISL3812_00196	A0A0U1LR09	A0A0U1LKI9	60S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family.	60S ribosomal protein L21-A.	0.999
PISL3812_02846	PISL3812_02052	A0A0U1LR09	A0A0U1LR92	60S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family.	54S ribosomal protein RML2, mitochondrial.	0.980
PISL3812_02846	PISL3812_04116	A0A0U1LR09	A0A0U1LWR8	60S ribosomal protein L16; Belongs to the universal ribosomal protein uL13 family.	60S ribosomal protein L2.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.804

expected number of edges:

12

PPI enrichment p-value:

2.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

7 of 82

2.53

6.47

8.42e-14

GO:0019682

glyceraldehyde-3-phosphate metabolic process

4 of 8

3.3

5.04

6.78e-10

GO:0005975

Carbohydrate metabolic process

8 of 308

2.01

4.78

1.67e-12

GO:0006096

Glycolytic process

4 of 21

2.88

4.28

1.14e-08

GO:0019637

Organophosphate metabolic process

10 of 677

1.77

4.26

4.29e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

5 of 211

1.97

2.62

2.42e-06

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

4 of 144

2.04

2.25

2.58e-05

GO:0052591

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

2 of 2

3.6

2.11

0.00016

GO:0008929

Methylglyoxal synthase activity

2 of 2

3.6

2.11

0.00016

GO:0004807

Triose-phosphate isomerase activity

2 of 2

3.6

2.11

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.7

2.12e-07

GO:0005829

Cytosol

7 of 1756

1.2

1.32

2.25e-05

GO:0005739

Mitochondrion

4 of 1201

1.12

0.64

0.0243

GO:0005737

Cytoplasm

11 of 10623

0.61

0.54

5.51e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:9211740

(1997) An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks.

2 of 2

3.6

1.5

0.0020

PMID:35193395

(2022) Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates.

2 of 3

3.42

1.5

0.0020

PMID:34769888

(2021) Prevalence, Molecular Characterization and Antimicrobial Susceptibility of Clostridioides difficile Isolated from Pig Carcasses and Pork Products in Central Italy.

2 of 2

3.6

1.5

0.0020

PMID:34093163

(2021) Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.

2 of 2

3.6

1.5

0.0020

PMID:31547548

(2019) Enzymes from Marine Polar Regions and Their Biotechnological Applications.

2 of 4

3.3

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11044

Glycolysis, and Transketolase or transaldolase activity

5 of 12

3.22

6.02

9.38e-12

CL:11045

Glycolysis, and Phosphopyruvate hydratase complex

4 of 7

3.35

5.02

7.76e-10

CL:3319

Glycerol catabolic process, and Ethanolamine metabolic process

3 of 6

3.3

3.52

4.29e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu00051

Fructose and mannose metabolism

5 of 22

2.95

6.14

3.52e-12

aqu01200

Carbon metabolism

6 of 106

2.35

5.35

7.15e-12

aqu01230

Biosynthesis of amino acids

5 of 57

2.54

5.11

9.37e-11

aqu00010

Glycolysis / Gluconeogenesis

4 of 38

2.62

4.26

7.56e-09

aqu00030

Pentose phosphate pathway

3 of 22

2.73

3.32

6.76e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 20

2.9

4.29

1.16e-08

MAP-1483166

Synthesis of PA

4 of 29

2.74

4.08

2.23e-08

MAP-70263

Gluconeogenesis

4 of 55

2.46

3.48

1.98e-07

MAP-71387

Metabolism of carbohydrates

6 of 287

1.92

3.35

1.32e-08

MAP-70326

Glucose metabolism

4 of 65

2.39

3.34

3.13e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.81

1.34e-07

GOCC:0005737

Cytoplasm

11 of 5405

0.91

1.01

1.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

4 of 12

3.12

4.91

1.03e-09

KW-0312

Gluconeogenesis

2 of 3

3.42

2.29

7.46e-05

KW-0704

Schiff base

2 of 5

3.2

2.21

0.00010

KW-0456

Lyase

2 of 47

2.23

1.26

0.0044

KW-0413

Isomerase

2 of 57

2.14

1.21

0.0051

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00274

Fructose-bisphosphate aldolase class-I

2 of 2

3.6

1.79

0.00060

PF00121

Triosephosphate isomerase

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 58

2.44

2.76

5.64e-06

IPR035990

Triosephosphate isomerase superfamily

2 of 2

3.6

1.72

0.00080

IPR029768

Fructose-bisphosphate aldolase class-I active site

2 of 2

3.6

1.72

0.00080

IPR000741

Fructose-bisphosphate aldolase, class-I

2 of 2

3.6

1.72

0.00080

IPR000652

Triosephosphate isomerase

2 of 2

3.6

1.72

0.00080

(more ...)

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