SeMB42_g03545 protein (Synchytrium endobioticum)

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

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Experiments

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[Homology]

Score

SeMB42_g03545

PACT_coil_coil domain-containing protein. (1002 aa)

Predicted Functional Partners:

SeMB42_g02324

0.842

GUK1-2

0.793

SeMB42_g00835

0.791

SeMB42_g01896

0.784

SeMB42_g03541

0.767

SeMB42_g05033

0.766

SeMB42_g05905

0.739

KATNAL2

0.737

SeMB42_g00373

0.737

SeMB42_g05607

0.736

Your Current Organism:

Synchytrium endobioticum

NCBI taxonomy Id: 286115
Other names: S. endobioticum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GUK1-2	KATNAL2	A0A507CP55	A0A507CI73	Guanylate kinase.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.583
GUK1-2	SeMB42_g00835	A0A507CP55	A0A507DR75	Guanylate kinase.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.908
GUK1-2	SeMB42_g01896	A0A507CP55	A0A507CR43	Guanylate kinase.	Uncharacterized protein.	0.814
GUK1-2	SeMB42_g02324	A0A507CP55	A0A507DF56	Guanylate kinase.	Uncharacterized protein.	0.804
GUK1-2	SeMB42_g03545	A0A507CP55	A0A507D5X1	Guanylate kinase.	PACT_coil_coil domain-containing protein.	0.793
KATNAL2	GUK1-2	A0A507CI73	A0A507CP55	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Guanylate kinase.	0.583
KATNAL2	SeMB42_g02324	A0A507CI73	A0A507DF56	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.639
KATNAL2	SeMB42_g03541	A0A507CI73	A0A507D6F7	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Uncharacterized protein.	0.657
KATNAL2	SeMB42_g03545	A0A507CI73	A0A507D5X1	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	PACT_coil_coil domain-containing protein.	0.737
KATNAL2	SeMB42_g05033	A0A507CI73	A0A507CUC8	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	t-SNARE coiled-coil homology domain-containing protein.	0.737
SeMB42_g00373	SeMB42_g02324	A0A507DRD1	A0A507DF56	Uncharacterized protein.	Uncharacterized protein.	0.631
SeMB42_g00373	SeMB42_g03545	A0A507DRD1	A0A507D5X1	Uncharacterized protein.	PACT_coil_coil domain-containing protein.	0.737
SeMB42_g00373	SeMB42_g05607	A0A507DRD1	A0A507CQK7	Uncharacterized protein.	Spindle pole body component.	0.458
SeMB42_g00373	SeMB42_g05905	A0A507DRD1	A0A507D233	Uncharacterized protein.	Spindle pole body component.	0.643
SeMB42_g00835	GUK1-2	A0A507DR75	A0A507CP55	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Guanylate kinase.	0.908
SeMB42_g00835	SeMB42_g02324	A0A507DR75	A0A507DF56	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.982
SeMB42_g00835	SeMB42_g03545	A0A507DR75	A0A507D5X1	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	PACT_coil_coil domain-containing protein.	0.791
SeMB42_g01896	GUK1-2	A0A507CR43	A0A507CP55	Uncharacterized protein.	Guanylate kinase.	0.814
SeMB42_g01896	SeMB42_g02324	A0A507CR43	A0A507DF56	Uncharacterized protein.	Uncharacterized protein.	0.545
SeMB42_g01896	SeMB42_g03545	A0A507CR43	A0A507D5X1	Uncharacterized protein.	PACT_coil_coil domain-containing protein.	0.784

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Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

10

PPI enrichment p-value:

0.6

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006783

Heme biosynthetic process

7 of 28

2.09

4.42

9.99e-11

GO:0006782

Protoporphyrinogen IX biosynthetic process

5 of 21

2.07

3.26

1.08e-07

GO:0019438

Aromatic compound biosynthetic process

8 of 319

1.1

1.26

2.55e-06

GO:0018130

Heterocycle biosynthetic process

8 of 362

1.04

1.14

6.20e-06

GO:1901362

Organic cyclic compound biosynthetic process

8 of 369

1.03

1.12

6.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004655

Porphobilinogen synthase activity

2 of 2

2.7

0.98

0.0165

GO:0016836

Hydro-lyase activity

3 of 49

1.48

0.65

0.0475

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 374

0.9

0.66

0.0049

GO:0005737

Cytoplasm

9 of 1536

0.46

0.32

0.0228

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6283

Porphyrin biosynthesis, and Cytochrome C assembly protein

6 of 10

2.47

5.01

1.08e-10

CL:6285

Siroheme metabolic process, and Cytochrome C assembly protein

3 of 5

2.47

2.28

5.30e-05

CL:1639

Fatty acid biosynthesis, and Acyl transferase

2 of 6

2.22

1.02

0.0125

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dti00860

Porphyrin and chlorophyll metabolism

6 of 48

1.79

2.99

3.37e-08

dti01110

Biosynthesis of secondary metabolites

7 of 347

1.0

0.99

6.41e-05

dti01120

Microbial metabolism in diverse environments

6 of 317

0.97

0.85

0.00053

dti01100

Metabolic pathways

7 of 844

0.62

0.43

0.0109

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

2 of 9

2.04

1.31

0.0030

MAP-168256

Immune System

2 of 20

1.7

1.08

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

6 of 12

2.4

5.06

5.03e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030656

Delta-aminolevulinic acid dehydratase, active site

2 of 2

2.7

0.79

0.0372

IPR016036

Malonyl-CoA ACP transacylase, ACP-binding

2 of 3

2.52

0.79

0.0372

IPR014043

Acyl transferase

2 of 3

2.52

0.79

0.0372

IPR001731

Delta-aminolevulinic acid dehydratase

2 of 2

2.7

0.79

0.0372

IPR001227

Acyl transferase domain superfamily

2 of 3

2.52

0.79

0.0372

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01004

Delta-aminolevulinic acid dehydratase

2 of 2

2.7

1.39

0.0030

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