node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OCQ53683.1 | gcvH | Ppb6_01085 | Ppb6_01622 | 2-oxoisovalerate dehydrogenase subunit beta. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.926 |
OCQ53683.1 | gcvP | Ppb6_01085 | Ppb6_01623 | 2-oxoisovalerate dehydrogenase subunit beta. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.401 |
OCQ53683.1 | gcvT | Ppb6_01085 | Ppb6_01621 | 2-oxoisovalerate dehydrogenase subunit beta. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.835 |
OCQ53683.1 | glyA | Ppb6_01085 | Ppb6_03583 | 2-oxoisovalerate dehydrogenase subunit beta. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.508 |
OCQ53683.1 | gor | Ppb6_01085 | Ppb6_00018 | 2-oxoisovalerate dehydrogenase subunit beta. | Glutathione reductase. | 0.999 |
OCQ53683.1 | lipA | Ppb6_01085 | Ppb6_01271 | 2-oxoisovalerate dehydrogenase subunit beta. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.674 |
OCQ53683.1 | lipB | Ppb6_01085 | Ppb6_01270 | 2-oxoisovalerate dehydrogenase subunit beta. | Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.648 |
OCQ53683.1 | lpdA | Ppb6_01085 | Ppb6_01601 | 2-oxoisovalerate dehydrogenase subunit beta. | Dihydrolipoyl dehydrogenase. | 0.999 |
OCQ53683.1 | odhB | Ppb6_01085 | Ppb6_01084 | 2-oxoisovalerate dehydrogenase subunit beta. | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex. | 0.999 |
OCQ53683.1 | sucA | Ppb6_01085 | Ppb6_02893 | 2-oxoisovalerate dehydrogenase subunit beta. | 2-oxoglutarate dehydrogenase E1 component. | 0.944 |
gcvH | OCQ53683.1 | Ppb6_01622 | Ppb6_01085 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoisovalerate dehydrogenase subunit beta. | 0.926 |
gcvH | gcvP | Ppb6_01622 | Ppb6_01623 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | Ppb6_01622 | Ppb6_01621 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA | Ppb6_01622 | Ppb6_03583 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.902 |
gcvH | gor | Ppb6_01622 | Ppb6_00018 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glutathione reductase. | 0.861 |
gcvH | lipA | Ppb6_01622 | Ppb6_01271 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.940 |
gcvH | lipB | Ppb6_01622 | Ppb6_01270 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.916 |
gcvH | lpdA | Ppb6_01622 | Ppb6_01601 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoyl dehydrogenase. | 0.886 |
gcvH | odhB | Ppb6_01622 | Ppb6_01084 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex. | 0.854 |
gcvH | sucA | Ppb6_01622 | Ppb6_02893 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase E1 component. | 0.864 |