STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadRTrifunctional NAD biosynthesis/regulator protein NadR. (415 aa)    
Predicted Functional Partners:
cobB_2
NAD-dependent protein deacylase; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.985
yvoA
HTH-type transcriptional repressor YvoA.
   
  
 0.941
OCQ51651.1
Hypothetical protein; Belongs to the UPF0301 (AlgH) family.
   
    0.940
parD1
Antitoxin ParD1.
   
    0.939
OCQ51140.1
Hypothetical protein.
   
    0.938
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.859
ppnK
Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.834
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.
    
 0.824
pncC
Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.
    
 0.822
radA
Hypothetical protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
       0.805
Your Current Organism:
Photorhabdus australis
NCBI taxonomy Id: 286156
Other names: ACM 5210, CIP 108025, DSM 17609, P. australis, Photorhabdus asymbiotica subsp. australis, Photorhabdus asymbiotica subsp. australis Akhurst et al. 2004, strain 9802892
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