Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
query proteins and first shell of interactors
second shell of interactors
proteins of unknown 3D structure
some 3D structure is known or predicted
Edges represent protein-protein associations
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|cbpD||Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity (389 aa)|| |
Predicted Functional Partners:
Belongs to the glycosyl hydrolase 18 family.
| || || ||0.967
Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase . Autocatalyses processing of its pro-peptide (PubMed:9642203, PubMed:1744034). Processes the pro-peptide of pro-chitin-binding protein (cbpD) . Involved in the pathogenesis of P.aeruginosa infections. ECO:0000269|PubMed:1597429, ECO:0000269|PubMed:1744034,
| || || || || || ||0.924
Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly . Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases . Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, [...]
| || || || || || ||0.685
Belongs to the peptidase M10B family
| || || || || || || ||0.683
Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients
| || || || || || || ||0.674
General inhibitor of family S1 serine proteases.
| || || || || || || ||0.672
annotation not available
| || || || || || || ||0.624
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38
| || || || || || || ||0.603
annotation not available
| || || || || ||0.594
Belongs to the bacterial solute-binding protein 3 family.
| || || || || || || ||0.591
Your Current Organism:
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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