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glnE protein (Pseudomonas aeruginosa) - STRING interaction network
"glnE" - Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme in Pseudomonas aeruginosa
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glnEBifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] (982 aa)    
Predicted Functional Partners:
glnD
Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism (900 aa)
 
   
  0.931
glnA
glnA- glutamine synthetase, type I (469 aa)
 
     
  0.855
rfaC
heptsyl_trn_I- lipopolysaccharide heptosyltransferase I (355 aa)
        0.833
glnK
annotation not available (112 aa)
 
 
  0.821
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (307 aa)
              0.771
rfaF
ADP-heptose-LPS heptosyltransferase homolog; heptsyl_trn_II- lipopolysaccharide heptosyltransferase II (345 aa)
 
        0.733
DR97_2361
annotation not available (492 aa)
   
   
  0.714
rfaP
Lipopolysaccharide core heptose(I) kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core (268 aa)
   
   
  0.712
wapP
annotation not available (244 aa)
   
   
  0.703
rfaG
annotation not available (373 aa)
              0.676
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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