The upcoming version of STRING is available for preview: it includes new data, new enrichment categories (e.g. diseases and tissues) and covers 14000 fully sequenced genomes.
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
estA
annotation not available (646 aa)
Predicted Functional Partners:
lipC
annotation not available
0.863
plpD
annotation not available
0.761
iscA
Putative iron-binding protein; iscA: iron-sulfur cluster assembly protein IscA
0.760
eprS
Serine protease; Autotrans_barl: outer membrane autotransporter barrel domain protein
STRING Data Update
