STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
emrBefflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 family protein; Belongs to the major facilitator superfamily (509 aa)    
Predicted Functional Partners:
emrA
Multidrug resistance protein A; RND_mfp: efflux transporter, RND family, MFP subunit
 
 
 0.978
macB
Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
   
 
 0.895
opmG
Uncharacterized protein; outer_NodT: efflux transporter, outer membrane factor (OMF) lipo, NodT family protein
 
  
 0.887
marR
annotation not available
 
 
 
 0.873
acrA
Acriflavine resistance protein A; RND_mfp: efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
  
 
 0.818
DR97_697
Putative multidrug resistance efflux pump; RND_mfp: efflux transporter, RND family, MFP subunit
 
 
 0.778
rnd
Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family
      
 0.777
mdr
Uncharacterized protein; RND_mfp: efflux transporter, RND family, MFP subunit
 
 
 0.738
DR97_5105
Secretion protein; RND_mfp: efflux transporter, RND family, MFP subunit
 
 
 0.735
acrD
2A0602: RND transporter, hydrophobe/amphiphile efflux-1 family protein
    
 
 0.681
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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